England skipper Harry Kane will be an injury absentee for Thursday's game against Wales at Wembley, a rare missed international for the 30-year-old after receiving a kick on the ankle when playing for Bayern Munich at the weekend.
Having started the season in supreme fashion, Kane would have been relishing the opportunity to add to his 74 England goals but will have to wait for Tuesday's trip to Latvia while Thomas Tuchel gets the opportunity to look at those who can step up to cover his captain's absence.
Jordan Henderson, John Stones or Declan Rice are the contenders to take Kane's armband.
Wales boss Craig Bellamy had been preparing to face Kane, calling him 'the most complete player I've seen at this present moment' when talking to the media ahead of the game.
Although Bellamy will have half an eye on the crucial World Cup qualifier with Belgium next week, his competitive instincts will still be in full flow as he looks to plot a win at Wembley.
The game against Wales has been designated as the Alzheimer's Society International and players from both sides will walk out with 22 fans living with dementia in a powerful message designed to highlight awareness of the UK's biggest killer.