It is nearly a year since the Borussia Dortmund man, scorer of the winning goal in the 2014 World Cup Final, has played for his national team due to injury problems.
Similarly back in the fold after a lengthy injury absence is Manchester City midfielder Ilkay Gundogan as the world champions begin their preparations in earnest for the defence of their crown with matches against England and France.
They will be followed up by another double-header, in March, against Spain and Brazil as Germany seek to step up from a comfortable qualification group with a quartet of tougher tests.
Earning his first call-up is RB Leipzig full-back Marcel Halstenberg but big names who miss out through injury include Bayern duo Manuel Neuer and Thomas Muller.
Although their competition record needs no further introduction, Germany also added the Confederations Cup to their list of honours earlier this year, Low showing the strength in depth at his disposal by resting a number of top stars for that tournament and yet still seeing his side lift the trophy.